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NAD + and precursors supplementation NAD + can be directly supplemented intravenously to increase cellular NAD + levels, which has been observed in healthy and elderly cohorts, suggesting improvements in cognitive function and increased expression of antioxidant genes, although these trials were conducted in small cohorts 66,116,117
In contrast, excessive or sustained activation of TLRs can promote chronic inflammation and has been implicated in the pathogenesis of numerous immune-mediated disorders (262)
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