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Well look at medical conditions that make it risky, possible drug interactions, and the right dosage to avoid side effects
Healthcare professionals have not identified any serious side effects from high-dose vitamin B12 supplementation
A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
However, it interfere with the effectiveness of some others medications so it's important to let your doctor know if you are considering having an injection or supplements
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