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The preclinical evidence base is substantial
Ask which medication class is most appropriate for your specific health situation, what weight loss and metabolic improvements you might realistically expect, what side effects are most likely and how they can be managed, how long you should expect to take the medication, what happens if you stop treatment, and what lifestyle changes should accompany medication therapy
Physiol Behav 283: 114622
2a), along with proteins related to fat mass and function, weight loss, CVD, endothelial function, lipid metabolism, pancreatic endocrine and exocrine function, inflammation and possibly cancer risk
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