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K., & Hartman, M
Mediation analysis from the STEP trials found that of the additional 7.6-14.4% weight loss achieved with semaglutide versus placebo, less than 1 percentage point was mediated by gastrointestinal adverse events
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Retatrutides numbers are genuinely impressive and its mechanism is genuinely novel, but impressive numbers in an earlier-stage program is not the same claim as proven superiority. The two statements are often conflated in popular coverage, and keeping them distinct is the single most important habit for reading this comparison accurately
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