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In the lipids and lipid-like molecules and nucleosides, nucleotides and analogs, the metabolites with the greatest increase were glutarate semialdehyde and deoxyuridine, while the metabolites with the greatest decrease were heptanoic acid and nicotinic acid mononucleotide, respectively (Additional file 4: Figure S4, Additional file 5: Fig

However, given the fundamental role of energy metabolism in biological processes and current research evidence, investigations focusing on lactate and histone lactylation modifications represent promising research directions for developing therapeutic strategies against metabolic diseases, particularly malignancies

There is still a need for further improvement in our understanding of the molecular mechanisms underlying endothelial dysfunction, platelet hyperactivity, high blood pressure, and vascular damage

Itching of the skin triggered by gut inflammation may start a self-perpetuating itch-scratch-itch cycle