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demonstrated that contrary to expectations, subsets of VANs containing GLP-1 receptor (GLP-1R) detected stomach and intestinal stretch and, interestingly, had no impact on nutrient sensing, which was instead regulated by G protein-coupled receptor 65 (GPR65)-positive neurons 32

While semaglutide itself does not appear to directly promote kidney stone formation through its mechanism of action, patients experiencing significant gastrointestinal symptoms or rapid weight loss may face increased risk if adequate hydration is not maintained

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Demographic patterns suggest that providersboth medical and insurancemust balance clinical needs and access considerations