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In some cases, prescribers may consider compounded medications when individualized formulations are appropriate

No direct kidney damage from tirzepatide has been documented in the SURMOUNT trials

One literature review published in JAMA in April 2025 by a group of Irish researchers stated that GLP-1 drugs are known to reduce inflammation, improve insulin signaling, and promote neurogenesis, all of which could protect against cognitive decline. These potential benefits could also have an effect on cancer outcomes

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