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Unlike fat-soluble vitamins, B12 does not accumulate in body tissues to toxic levels

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Vitamin B3 (niacin) is involved in the citric acid cycle, in acetyl-CoA formation, and its coenzyme transitions from NAD+ to NADH

That said, patients with active diabetes or significant metabolic dysfunction should have any investigational peptide protocol reviewed by their endocrinologist or primary care physician alongside their supervising aesthetic medicine provider