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On the other hand, in this study, the observed downregulation of bta-miR-22-3p and rno-miR-494 and the upregulation of oar-miR-3958-3p and oar-miR-125b in frozen-thawed ram spermatozoa following intraepididymal PRP administration may be explained by the ability of miRNAs to: (a) activate or inhibit antioxidant enzymes, (b) target genes related to ROS, and (c) modulate specific transcription factors that regulate gene expression (Babu and Tay 2019
J Biol Chem (2006) 281(45):3412434
They modified the Val-Cit-p-aminobenzylcarbamate (PABC) linker technology developed by Seagen which has been employed on three of the nine approved antibody-drug conjugates and tested on more than 20 clinically relevant molecules 50
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