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GLP-1 and GIP therapies are among the most promising tools in modern weight management
A: Alternatives to estradiol patches include FDA-approved transdermal gels and sprays, oral estradiol (with a different clot-risk profile), vaginal estrogen preparations for genitourinary symptoms, and compounded transdermal estradiol creams from PCAB-accredited pharmacies
GLP-1 can elevate the turnover of dopamine in the brain amygdala through dopamine receptor 2 signaling (Lietzau et al., 2020)
To put those numbers in context that matters for Canadian researchers: a person starting at 160 lbs loses approximately 39 lbs at the 12mg dose
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