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Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation

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doi: 10.1128/spectrum.04711-22 112 PersaudRLiSCChaoJDForestieriRDonohueEBalgiADet al

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NNMT depletes cells of NAD+, a crucial coenzyme required for mitochondrial function and energy production

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It is essential for neurological function and DNA synthesis

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