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Mechanistically, dulaglutide downregulates matrix metalloproteinases (MMP-3 and MMP-13) and aggrecanases, protecting the articular extracellular matrix [50]

While drugs like Wegovy can help people continue to lose weight or lose weight they regained years after their operation, she notes that it may be useful for some people to take Wegovy first because it can lower their overall surgical risks and make them more likely to qualify for weight loss surgery

Important context for emerging research: GLP-1 research may eventually inform future understanding of overlapping reward pathways Current evidence does not support GLP-1s as a treatment for co-occurring conditions GLP-1 medications are not part of existing evidence-based treatment pathways At this time, specialized, integrated care remains the standard for treating co-occurring eating disorders and substance use disorders

Vitamin B12 deficiency is one of the most documented concerns with GLP-1 therapy, and adequate B12 is essential for energy production, neurological function, and red blood cell formation