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This suggests that downregulation of MYC contributes to, but is not the sole mechanism of, growth inhibition by SPA/BAT
Sibutramine, lorcaserin, naltrexone-bupropion the kilograms came off, the events did not follow. For a long time, the assumption was that weight loss itself was the protective ingredient, and the failures were waved off as too modest, too short, or in the wrong patients
Lancet 2019;393:1937-47.PubMed 21
PMID: 78
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