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In a series of experiments in monkeys with obesity and diabetes, the tri-agonist SAR441255 showed superior metabolic outcomes to that achieved with a comparator dual GLP-1/GCG RA
No human study has established a route conversion or shown that they match oral exposure
& Lemon, S
It is a 13-amino-acid chain held in a specific three-dimensional shape by hydrogen bonds and hydrophobic interactions, and that shape determines whether it binds to melanocortin-1 receptors or does nothing at all
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