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Hypokalemia is essentially a functional ATP deficit from the pumps perspective
But good quality human clinical trials of the combination are limited and the average effects seen for each on body composition are modest
(August 2018)
"Head-to-head studies are the gold standard for clinicians assessing the efficacy of investigational treatments, and these results show that all three doses of tirzepatide delivered superior A1C and weight reductions compared to the highest approved dose of semaglutide to treat type 2 diabetes," said Juan Pablo Fras, M.D., Medical Director, National Research Institute and Principal Investigator of SURPASS-2
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