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Supplements That Are Safe but may not be very helpful specifically to isotretinoin therapy These supplements are commonly asked about but dont help isotretinoin side effects: Collagen powders fine, but wont reduce dryness Protein powders safe Magnesium helps muscle cramps, not acne Vitamin C safe, but no proven benefit Iron only take if deficient Turmeric/curcumin generally safe but may interact with blood thinners Other topical therapies to help with isotretinoin side effects These arent supplements but are extremely effective for managing dryness: Urea-based moisturisers (510%) Excellent for flaking or sensitivity

You are a Vegetarian or Vegan Since the primary dietary sources of B12 come from animal products, strict vegetarians and vegans are at very high risk of developing a B12 deficiency

Aspirin, ibuprofen, or naproxen are nonsteroidal anti-inflammatory drugs (NSAIDs) that can relieve arthritis pain

Co-immunoprecipitation and Western blot Co-immunoprecipitation and Western Blot analyses were performed as previously described [27]