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Studies have found that people who used tirzepatide injections such as Zepbound lost more weight and were more likely to reach specific weight loss targets than those using semaglutide medications such as Wegovy

It belongs to a class of medications called GLP-1 receptor agonists, which work by stimulating the release of insulin and reducing the production of glucose in the liver

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The SURMOUNT-5 authors hypothesize that GIP receptor expression in subcortical brain regions that regulate food intake doesn't fully overlap with GLP-1 receptor expression, which may explain the additive effect