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24 25 26 Hormone therapy is not a universal fix, and outcomes vary based on timing, formulation, and individual biology
High-intensity interval work (HIIT training), heavy resistance training, endurance blocks, and competition schedules can create large amounts of oxidative stress
The next-generation of antioxidant interventions will focus on spatial and temporal precision, like the NOX isoform-specific nanotherapy based on lipid nanoparticles encapsulating NOX1 siRNA ( Chronotherapeutic Nrf2 activation is being studied as an alternative for HTN treatment (Serrano and Medina, 2025)
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