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A small randomized study (5) with N=60 patients where melatonin was orally administrated (3mg/day) from day 3-5 until hCG administration (oocyte collection) showed: a higher number of total oocytes (11.5 vs 6.9) higher number of mature oocyte (9% vs 4.4%) a higher rate of embryos transferred (69.3% vs 44.8%) These results were confirmed in another independent trial (6)
Chronic inflammation triggers the release of pro-inflammatory cytokines such as TNF-, which in turn suppresses FGF-21 expression [217]
This activation enhances iron accumulation and lipid peroxidation, accelerating neuronal damage
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