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Chronic ICV administration of oxyntomodulin, a GLP-1R agonist, in mice decreased body weight despite having no significant effects on food intake (Lockie et al., 2012)
Based on 78 systematic reviews of 496 primary studies in 177,373 participants
Although there are legitimate ways to obtain discounted Rybelsus, online pharmacies offering very cheap GLP-1 medications may not be safe to use
The evidence remains observational, so these agents should be viewed as metabolic adjuncts, not replacements for established HS therapies
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