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303 , F681F688 (2012)
That is why it can be swallowed at all, and why it behaves like a small-molecule drug: real oral absorption, first-pass liver metabolism, a huge volume of distribution (39 L/kg in mice), and off-target enzyme binding
The last term is the activation of CBS by oxidative stress [25, 26], which is represented by the concentration of H 2 O 2
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