Clearance of p16^Ink4a-Positive Senescent Cells Delays Aging-Associated Disorders
For example, improved histopathological findings in diabetes (liver and kidney) (Reference Alam, Iqbal and Naseem31) , hepatotoxicity (Reference Al-Harbi, Imam and Nadeem25,Reference Bashandy, Ebaid and Moussa26) acute lung injury (Reference Al-Harbi, Imam and Nadeem22) , renal toxicity (Reference Alhazza, Hassan and Ebaid23) , ulcerative colitis (Reference Karakoyun, Erta and Yksel27) , spinal cord injury (Reference Sakarcan, Erahin and Eminolu30) and abdominal aortic aneurysm (Reference Yu, Morimoto and Yu32) have been indicated following riboflavin administration
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Proteasome activity is notably reduced in several tissues in obesity and T2DM