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The main constraint of curcumin lies in its limited bioavailability, with only a minimal fraction of the substance reaching the bloodstream in a biologically active form
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10.1073/pnas.0506836103 Proc
It sheds light on the emerging knowledge regarding the peptides, their specific receptors on brain endothelial cells, the selection of drug payloads, the design of DSIP-CBBBP, mechanisms of brain entry, and the efficiency of delivery to the brain ( On the other hand, the lack of a significant anxiolytic effect with GABA treatment raises questions about its bioavailability or receptor interactions in the specific context of the EPM test, possibly due to differences in the route of administration, dosage, or the animal models specific pathology
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