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For background on the copper tripeptide itself, Wikipedias GHK-Cu overview provides foundational context

NAC can be taken on an empty stomach, but if you have a sensitive digestive system, taking it with a small snack or meal can help prevent mild discomfort

Viennois and colleagues (Cell Mol Gastroenterol Hepatol, 2016, PMID 27458604) reported that the effect was lost in PepT1-knockout mice, making the transporter the gating step