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Berberine, an alkaloid from plants like goldenseal and barberry, primarily activates AMPK (adenosine monophosphate-activated protein kinase) and inhibits mitochondrial complex I, improving mitochondrial function and enhancing glucose uptake in muscle and adipose tissue
To be precise about the evidence: these are wellness-supportive ingredients, not treatments for anything GLP-1-related, and they will not preserve muscle or fix a nutrient gap
The SURMOUNT trials for weight management told the same story
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