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There are no reported risks associated with large doses of B12, since the vitamin is water soluble and excess amounts are flushed out of the system
Medications like omeprazole, cimetidine, lansoprazole, and folate can interfere with B12 absorption
This means they might need different amounts of B12 than others
People who have had intestinal surgery, such as weight loss surgery, or who have digestive disorders, such as celiac disease or Crohns disease, which may reduce the amount of vitamin B12 the body can absorb
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