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A dense extracellular matrix (ECM),rich in collagen and hyaluronic acid, forms a physical barrier that restricts drug penetration and distribution
5.Gerstner T, Buesing D, Longin E, et al
Manifestations of oxidative stress have also been reported in the hippocampus and temporal cortex of ASD patients [119, 120]
Although NPH is potentially reversible 9 , clinical management and patient selection remain challenging due to symptom overlap and frequent comorbidity with other neurodegenerative disorders (NDs), such as Alzheimers disease and Parkinsons disease 2,1012 , as well as other age-related comorbidities 13
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