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Management: Start with lower doses and titrate slowly
The gradual nature of micro-dosing benefits from extended consistent application
The pump mechanism allows for controlled application
Glucose removal lowers TCA cycle intermediates and pulls glutamate through GDH Removal of glucose from the media (Figure 2, dotted gray line from GLC) deprives cells of pyruvate input into the TCA cycle and a fall in the intermediate (KG) pool level[5] as reflected by a drop in glutamate [7]
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