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10.1186/s12916-023-03019-x 16

Product Attributes CAS # : 2103905-91-3 Molecular Formula : C201H325N65O67 Sequence (AA) : (D-Arg)9-LTLRKEPASEIAQSILEAYSQNGWANRRSAGGKRPPPRRRQRRKKRG Molecular Weight : ~4598 g/mol PubChem CID : N/A (peptide not indexed) Half-Life : ~2-4 hours Synonyms : Proxofim, FOXO4-D-Retro-Inverso, FOXO4-p53 Interfering Peptide Type : Synthetic D-retro-inverso peptide (senolytic research compound) Research Focus : Longevity & Senescence, Cellular Repair Scientific References Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging Animal | In vitro FOXO4-DRI peptide selectively induces apoptosis in senescent cells Animal | In vitro Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration Animal | In vitro Cellular senescence: Defining a path forward Observational | Animal | In vitro The role of senescent cells in ageing Animal | In vitro FOXO4 peptide disrupts FOXO4-p53 interaction to target senescent cells Animal | In vitro Senolytic therapy alleviates age-associated bone loss in mice Animal | In vitro Therapeutic interventions for aging: the case of cellular senescence Observational | Animal | In vitro Included In The Box Every product arrives in a premium, custom-designed PEPTIDE.Power box , engineered for convenience, hygiene, and safe storage in your refrigerator

Key physiological roles include: Energy production through glycolysis and oxidative phosphorylation DNA repair and genomic stability maintenance Regulation of circadian rhythm through sirtuin activity Cellular signalling and calcium homeostasis It is important to note that in the UK, nicotinamide riboside chloride is an authorised novel food with specified maximum daily intake limits, while NMN is not currently authorised as a novel food

What Is FOXO4-DRI in Cellular Senescence Research