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As the only obligate cytosolic pathogens, Rickettsia and their close relatives are useful models to understand how bacteria parasitize eukaryotic metabolites, as these microbes steal over fifty nutrients from their hosts and evolved a reduced genome that lost the ability to synthesize many metabolites de novo, including GSH 10

A comprehensive understanding of the mechanisms of action involving NBCs, individually or in combination with TOP2 inhibitors, is imperative for effective cancer treatment

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