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The combination gives far more actionable information than serum B12 alone

Preclinical toxicology studies in rats and dogs at doses up to 20 times the projected human therapeutic dose showed no organ toxicity, no changes in IGF-1 levels, and no alterations in glucose homeostasis [4]

In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)

The gut settles into a calmer rhythm, which lowers background fatigue across the day