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Misregulated activation of CDKs and their cyclin partners, especially cyclin D1, is a feature of oncogenic transformation (57)

Together, findings from these two studies [25, 28] may suggest that antidepressants should generally not be used in two-thirds of patients with bipolar depression who present with subtly increased psychomotor tempo, pressured speech and racing thoughts

That does not make it an approved treatment, but it does make it easier to study as a defined research compound

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