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Exendin-4 and DPP-4 deficiency prevented vasoconstriction and multiple organ injury after LPS treatment, and improved survival in endotoxemic rats (31)
The 2.5 mg dose is just to begin treatment and is not meant to be used long-term
Importantly, these medications carry a boxed warning about thyroid C-cell tumors observed in rodent studies and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Gradual potency loss from temperature exposure does not change the solution appearance
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