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IV Therapy during pregnancy: is it safe
NAC supplementation (600 mg/day) has been shown to improve flow-mediated dilation in patients with chronic heart failure in a small RCT (Andrews et al., J Am Coll Cardiol, 2001) [65]
These factors, combined with the complexity of designing clinical trials that adequately account for heterogeneity, timing, and appropriate endpoints, contribute to the difficulty in demonstrating clinical efficacy
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