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A broad panel of antibodies was employed, including those for FOXO4, p53, phospho-p53, p21, p16, cleaved-Caspase3, BAX, BCL-2, testosterone synthesis enzymes (3-HSD, CYP11A1, CYP17A1), and various SASP factors (IL-1, IL-6, TNF-, TGF-)

In previous studies, ROS levels were increased in patients with tendinopathy (Yoshida et al., 2020), and an in vivo study showed that tendinopathic changes in the patellar tendon are attributed to H 2 O 2 (Talla and Veerareddy, 2011)

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Your doctor may also take your medical history and perform a physical exam and blood tests to determine if another health condition, like prediabetes or thyroid disease, is causing your acanthosis nigricans