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The practical lesson: higher doses do not always mean better outcomes when you factor in tolerability
In vitro studies confirm that linagliptin suppresses the proliferation of several tumor cell lines, including colorectal cancer HCT116, breast cancer MCF-7, and liver cancer HepG2, via mechanisms that involve cell cycle arrest and apoptosis induction [96]
Consistent with previous reports, the expression level of LAT1 in tumor cells was higher than that in normal cells, and the LAT1 expression level correlated with the amount of LAAM GSH-CQDs that penetrated cells in various cell lines 4
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