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Conclusion In conclusion, this study reveals that excessive GSH intake may contribute to chemotherapy resistance in breast cancer patients, identifying high GSH intake as an independent risk factor for tumor recurrence

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Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) constitutes a central regulator of cellular defense mechanisms, including the regulation of antioxidant, anti-inflammatory and mitochondrial pathways, making it a highly attractive therapeutic target for disease modification in neurodegenerative disorders