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Notably, in the lumbar spine, prolonged CR (20 or 74 weeks) yielded graded benefits in trabecular volumetric BMD, bone volume fraction, and trabecular number
It is recommended to wait 90 to 120 minutes after waking to consume caffeine (unless you exercise first thing in the morning), and to stop caffeine consumption by midafternoon to ensure it wont affect your ability to fall asleep at night
doi: 10.3389/fphar.2022.1026182
The lean mass loss seen with these drugs largely mirrors what occurs with an equivalent hypocaloric diet and is driven mainly by a steep caloric deficit, lack of resistance training, and inadequate protein intake, not a unique catabolic effect of the medication
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