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The Starter Dose Objective The initial dose of 0.25 mg is generally considered a loading dose or a starter dose. Its primary purpose is to get your body used to the medication and minimize gastrointestinal side effects like nausea or cramping, which are discussed in Common GLP-1 Side Effects: What to Expect
For glycemic control, these medications typically reduce HbA1c by 1.0-2.0% in patients with type 2 diabetes
Thus, future clinical trials must assess the long-term effect of GLP-1RA treatment
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