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Senescent cells, through the secretion of SASP factors into their environment, influence neighboring non-senescent cells and the extracellular matrix (ECM), leading to inflammation, fibrosis, and programmed death of healthy cells, while simultaneously becoming resistant to apoptosis [34]
Even more concerning, nearly 80% of Black and Hispanic adults report never having a doctor or healthcare provider discuss PAD with them, despite being at higher risk
Akiko Sato (Kyushu University, Japan) for technical assistance concerning animal care and satellite-cell culture experiments
doi: 10.1016/j.bbrc.2010.12.077 71 NakamuraTTanimotoHMizunoYTsubamotoYNodaH
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