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Prolonged exposure to high cortisol is associated with weight gain (particularly central obesity), insulin resistance, hypertension, mood disturbances including anxiety and depression, impaired immune function, and bone density loss

Compare mole mapping to baseline

HPLC purity claims (often ~98%) vary by source

Ultimately, the decision between simultaneous initiation and sequential add-on therapy should be individualized, considering patient-specific factors such as comorbidities, baseline kidney function, and treatment goals

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