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The CAK-OTS964 structure reveals conformational flexibility of the inhibitor in the CDK7 active site and the absence of several key contacts, including those formed by CDK11 E445 and D522
Chemical Name: DSIP (Delta Sleep-Inducing Peptide) Molecular Formula: C35H48N10O15 Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (9-amino acid neuropeptide) Research Applications: Sleep cycle regulation studies Circadian rhythm modulation research Stress response and cortisol pathway analysis Pain perception and analgesic mechanism studies Hypothalamic-pituitary axis research Sleep architecture and REM cycle protocols Neuroendocrine system interaction studies Product Specifications: Form: Lyophilized powder Purity: High purity research grade Molecular Weight: 848.8 g/mol Storage: Store at -20C, protect from light and moisture Reconstitution: Use bacteriostatic water (not included) Stability: 24 months when stored properly, 30 days once reconstituted Research Background: DSIP is a naturally occurring neuropeptide originally isolated from the cerebral venous blood of rabbits in sleep-induced states
Selank was developed in Russia by the Institute of Molecular Genetics as an analog of tuftsin, a natural peptide from a region of the antibody immunoglobulin G
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