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2,28,34 Moreover, stimulation of NTS GLP-1 neurons inhibits hepatic glucose production without altering peripheral glucose uptake, illustrating the involvement of the central GLP-1 system in energy homeostasis and glucose metabolism

Abstract Background: Tirzepatide, a dual glucose-dependent insulinotropic polypeptide, (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has emerged as an effective therapy for obesity and type 2 diabetes mellitus (T2DM)

Yuksel, C., et al

Patients switching from Wegovy injection to oral semaglutide follow a straightforward protocol: stop the injection and start oral semaglutide 25 mg one week later