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In 1830, Andral and Cruveilhier first reported melanosis of the large intestine and suggested that it was related to the deposition of lipofuscin in the lamina propria of the large intestine
This potential is the sum of the concentration difference of protons (pH) across the IMM and the difference in electrical charge () across this membrane
Briefly, lungs were perfused with PBS, minced into small pieces and digested with collagenase A (2 mg/ml, Sigma-Aldrich, St
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