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Products applied to the skin rather than ingested also do not meet the FDA's regulatory definition of dietary supplements, placing herbal wellness patches in a distinct category with different oversight than both pharmaceutical drugs and oral supplements

With fresh approvals, mounting clinical evidence, and a surge in adoption by specialists far beyond endocrinology, these treatments are rewriting the rules for managing comorbid conditions and reshaping adjacent markets

Pagano G, Castello G (2012) Oxidative Stress and Mitochondrial Dysfunction in Down Syndrome

This is especially important in our modern world where were exposed to so many environmental toxins