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And if those conditions are met, can they move the needle on something actuarially relevant? While uncertainties remain, Bellomo said the emerging evidence increasingly points toward affirmative answers

Significant reductions (5% or more) usually manifest by month 3-4 with consistent dosing and adherence

Dramatically Improved Sleep Quality Often the first benefit noticed usually within 1-2 weeks: Deeper, more restorative sleep Faster sleep onset Fewer nighttime awakenings Wake feeling genuinely refreshed "Hot flashes are basically gone

CRUCIAL QUOTE "These drugs have the potential to cause significant damage to multiple critical organs, yet they provide meager benefits in reducing weight loss in obese and overweight patients," Dr