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Mechanistically, drugs such as mecamylamine act as noncompetitive antagonists at neuronal nicotinic acetylcholine receptors, producing a poretrapping block by entering and becoming trapped within the open ion channel (second panel)
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The strongest responses tend to come from people who are consistent with weekly dosing, follow through on lifestyle changes alongside medication, and work with a provider to titrate dosing at the right pace
Using both targets may provide broader appetite regulation than either alone
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