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Patients with a history of severe gastrointestinal disease, particularly those with inflammatory bowel disease, severe gastroesophageal reflux disease, or history of pancreatitis, require careful evaluation before considering this therapy

Because of this noxious effect, it was taken off the market.48 Pioglitazone is metabolized by the CYP2C8l and CYP3A4 system.49 There are no pharmacodynamic studies evaluating the effects of this drug in patients with CLD, and it may induce increase of body weight

Make sure to keep your doctor advised of your progress and contact them for assistance if you are not losing weight, are experiencing severe side effects, or have any questions

Specifically, it can worsen side effects like nausea, vomiting, dehydration, and acid reflux