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Participants were randomly assigned to receive either the higher 7.2 mg dose, the approved 2.4 mg dose, or a placebo for 72 weeks
Every 1-standard-deviation increase in p-tau217 was associated with a 2.43-fold higher hazard of developing mild cognitive impairment or dementia, and a 3.17-fold higher hazard for dementia specifically [2]
Whether that selectivity advantage holds at doses and durations used outside research settings remains unverified
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