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Parenteral administration is expected to dominate the market, accounting for 80% of the market share in 2026, as GLP-1 Receptor Agonists are commonly administered via injections for better absorption and efficacy
An initial analysis of the FDA adverse event reporting system (FAERS) data demonstrated no consistent trends in DKA with SGLT2i use over time [39], however an alternative cohort study of 50,220 individuals with type 2 diabetes showed the highest risk of DKA shortly after SGLT2i initiation, which subsequently reduced with time [40]
If peak-related side effects are your primary concern, daily dosing with a shorter-acting GLP-1 might be a better pharmacological fit than twice-weekly dosing with a longer-acting one
Common side effects include injection site reactions (pain, redness, swelling), gastrointestinal symptoms, and allergic reactions
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